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KMID : 0362319960210010366
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Journal of Korean Academy of Operative Dentistry
1996 Volume.21 No. 1 p.366 ~ p.374
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Testing of neuropeptide Y involvement in blood flow regulation in the feline dental pulp using d-myo-inositol-1,2,6-trisphosphate
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Abstract
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The purpose of this study was to investigate whether D - myo - inositol-1,2,6-trisphosphate (PP56) can effectively antagonize vasoconstriction caused kby neuropeptide Y in the dental pulp, and to understand involvement of neuropeptide Y in the
regulation of microcirculation in the dental pulp with the aim of elucidating neurogenic inflammation.
Experiments were performed on 7 cats anesthetised with sodium pentobarbital, and neuropeptide Y and a neuropeptide Y antagonist PP56 were injected close intra-arterially into the dental pulp. The probe of laser Doppler flowmeter was placed on the
buccal
surface of ipsilateral canine teeth to the drug administration and pulpal blood flow was measured.
Intra-arterial injection of neuropeptide Y(1.3-2.0㎍/kg) resulted in pulpal blood flow decrease of 37.37±5.73%(mean±SEM)(n=9). Intra-arterial injection of PP56(0.3mg/kg) alone changalone changed pulpal blood flow little by 1.03% reduction. The
effect
of neuropeptide Y in the presence of PP56 resulted in significantly less decreases in pulpal blood flow ranging from 27.17±5.37 to 16.63±3.48% from control as compared with neuropeptide Y alone(n=13). In effect, PP56 attenuated pulpal blood
flow
caused by neuropeptide Y.
Results of the present study have provided evidences that a non-peptide PP56 is capable of antagonizing vasoconstriction caused by neuropeptide Y in the feline dental pulp. In addition, they show functional evidences that neuropeptide Y plays an
active
role in modulating the microcirculation of the dental pulp.
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